The 1980s were the network's most successful period as a news provider with its local Sydney, Melbourne and Brisbane bulletins often rating highest for their 6pm timeslots.

Some of the best-known reporters and presenters who launched or spent a major part of their careers at Network 10 include Jana Wendt, Kerry O'Brien, Katrina Lee, Charles Slade, Ann Sanders, Steve Liebmann, Tim Webster, Ron Wilson, Anne Fulwood, Juanita Phillips, Harry Potter,[4] Liz Hayes, Jo Pearson, David Johnson, Bill McDonald, Chris Masters, Larry Emdur, Eddie McGuire, John Gatfield, Kay McGrath, Graeme Goodings, Sharyn Ghidella, Laurie Oakes, Geraldine Doogue, Helen Kapalos, Jennifer Keyte, Deborah Knight, Bruce McAvaney, Nathan Templeton, Mel McLaughlin, Karl Stefanovic, Mark Beretta, Amber Sherlock and George Donikian amongst others.

On 21 May 2014, Network 10 announced it would axe Wake Up and all national news bulletins on weekdays as part of a wider cost-cutting program with the loss of around 150 jobs, caused by poor ratings and advertising revenue.

Fill-in presenters for the bulletin include Ursula Heger, Lachlan Kennedy, Hugh Riminton, Kate Freebairn, Amanda Hart and Angela Bishop.

[22][18][19] 10 Late News airs weeknights at 10:30 pm and is presented from the network's Sydney studios by Ursula Heger.

Due to declining ratings and increased competition, the bulletin was axed with the final week of episodes hosted by Sandra Sully (news) and Brad McEwan (Sports Tonight) on Monday through Thursday, and Tim Webster on Friday 30 September 2011.

In September 2013, the bulletin was rebranded as Ten Eyewitness News: Late and Danielle Isdale replaced Macdonald after he resigned later that same month.

The lack of a separate up-to-date edition of Ten Eyewitness News Weekend for Perth has led to criticisms when outdated time-sensitive news has been broadcast in Western Australia, as in the case of a local 8-year-old junior drag racing accident victim who had died in hospital several hours prior to Ten airing the three-hour-old national bulletin reporting that she was still alive.

The bulletin has previously been presented by Natarsha Belling, Hermione Kitson, Mike Munro, Matt Doran, Bill Woods, Steve Liebmann, Tracey Spicer and John Gatfield.

Wilson moved to the networked Early News bulletin,[29] after presenting his final 5pm Sydney program as main anchor on Friday 16 January 2009.

[16] Fill-in presenters include Hugh Riminton, Lachlan Kennedy, Narelda Jacobs (news) and Amanda Hart (weather).

The network's Melbourne news operation was originally based at the Nunawading studios until a move to the Como Centre in 1992.

Mal Walden joined ATV-10 in April 1987, shortly after his abrupt sacking by HSV-7 - he took over the weekday 5pm bulletin in 1996 alongside Jennifer Hansen who was replaced by Helen Kapalos in 2006.

George Donikian was the main male fill-in during the 2000s, including presenting the Saturday 6pm bulletin during the AFL broadcasting rights.

During the 2000s, occasionally due to availability and network commitments, Walden or Kapalos would present solo (particularly after major events such as the AFL Grand Final).

Emma Notarfrancesco left after four and a half years (2010–2015), to work for Formula 1's Australian media team on Friday 20 February 2015.

[34] Fill in presenters include Candice Wyatt, Stephen Quartermain (News), Nick Butler and Caty Price (Sport), Brendan Crew and Steph Baumgartel (weather).

Former long-serving presenter Marie-Louise Theile left Ten News on 14 December 2007 to spend more time with her family.

[35] Other previous presenters include Geoff Mullins, Tracey Spicer, Brad McEwan and Bill McDonald, who left in November 2012 when his contract was not renewed due to cost-cutting measures.

Initially, then-presenters George Donikian and Nikki Dwyer relocated from Adelaide to present the new Melbourne based bulletin.

After 8 years co-anchoring with Donikian, Dwyer eventually resigned as presenter in late 2000 after she decided to move back to Adelaide, to begin starting a family.

Production of the Perth bulletin was initially moved to Pyrmont in 2000, citing high costs of converting the network's Dianella studios.

[40] The network denied that the move was related to the death of Charmaine Dragun as the decision to switch production had been made well beforehand.

[42] In September 2020, studio production for the Perth bulletin was transferred back to Sydney with Narelda Jacobs returning as anchor.

The formerly half-hour long show premiered on 20 July 2009 and is hosted by Waleed Aly, Sarah Harris and Sam Taunton on Monday to Thursday nights, and Hamish Macdonald, or Rove McManus, Georgie Tunny and Susie Youssef on Friday and Sunday nights, with rotating daily panellists that usually host once a week alongside the regulars.

The bulletin was revived on 4 November 2013 as Ten Eyewitness News: Early, airing from 5:30am to 6:30am on weekdays, immediately preceding the network's new breakfast program Wake Up.

In 1996, Jason Cameron took over as presenter for the next four years until production was moved to 10's Pyrmont news centre in Sydney, where the bulletin was hosted by Tracey Spicer and Natarsha Belling.

In 2007, after Tracey Spicer left the network the previous year, Natarsha Belling became the face of the bulletin and continued the role right through to the start of 2012.

The bulletin was retired with the launch of Breakfast but returned upon the axing of The Circle in late August 2012, this time airing at 10am on weekdays, presented by Ron Wilson.

[49] The program was axed again on Friday 30 November 2012, marking the final full-length national news to be presented by Ron Wilson after 33 years with Network 10.