Between World War I and II, the Regiment filled many different roles, including building their Barracks and various other construction around the base, and guarding the mail.

[1] After the end of World War II, the 10th Marines found themselves at Camp Lejeune, North Carolina, which would be their home until present day.

As the Korean War started, the 10th Marines were working with a skeleton crew, but five months later they were fully mobilized and back up to wartime strength and ready to fight.

The Regiment was tasked with providing fire support for the 2nd Marine Division in the war to oust Iraqi forces from occupied Kuwait.

Since 2003, the Regiment has continued to deploy battalion headquarters units and their subordinate batteries to Iraq to provide fire support and sometimes also act as provisional rifle companies especially in the Al Anbar province of western part of the country.