The 10th Submarine Squadron was an administrative unit of the Royal Navy.

The squadron was formed at HMNB Clyde, Faslane, Scotland, in the 1960s to direct the Resolution-class submarines equipped with Polaris missiles that formed part of the United Kingdom's strategic nuclear deterrent.

The four Resolution-class submarines would carry out a total of 229 operational patrols during their time in service with the squadron.

[1] The squadron would later direct the Vanguard-class submarines equipped with Trident missiles.

In February 2002 all existing squadrons were disbanded and replaced by three flotillas at the base ports of Devonport, Faslane and Portsmouth.