It borders the 5th and 12th arrondissement in the north, the 11th in the east, the 9th in the south, the 8th in the southwest and the 6th in the west.

It is governed locally together with the 9th arrondissement, with which it forms the 5th sector of Marseille.

The 10th arrondissement of Marseille includes six neighbourhoods (quartiers): la Capelette, Menpenti, Pont-de-Vivaux, Saint-Loup, Saint-Tronc, and La Timone and 25 IRIS including 24 IRIS housing and Prado Park.

The Capelette neighbourhood is very poorly served by public transport.

The Capelette district, named after the disused Capeletto chapel on Bonnefoy Boulevard, has a railroad bridge that crosses the avenue, as well as the church of St Laurent on St Jean Boulevard.