The infantry regiment was organized at Springfield, Illinois and mustered in on May 2, 1861 for a three-month service.

The regiment was transferred to Cairo, Illinois, for garrison duty until August 1861.

By the time the regiment was mustered out on August 1, 1861, they had lost four to disease.

The regiment was mustered out on July 18, 1865, at Camp Butler National Cemetery Camp Butler, Illinois.

The regiment suffered 5 officers and 143 enlisted men killed in action or mortally wounded and 3 officers and 109 enlisted men who died of disease, for a total of 260 fatalities.