Historically significant areas along the street include Squatter's Row, Little Italy, Little Bohemia, and Mount Vernon Gardens.
[2] Along with Squatter's Row, Little Bohemia, and Little Italy, there are several other neighborhoods along the route of 13th Street, including the Old Market, Spring Lake, and Deer Park.
Moses Block, Bohemian Cafe, Prague Hotel, Sokol Auditorium, Gallagher Building, and Stabrie Grocery.
Father Flanagan's first boys home was located along South 13th Street at the Old German Civic Center.
After momentarily becoming Fort Crook Road, the street continues south into Bellevue and terminates in rural Sarpy County.