It goes east through farmland to Bellwood, then ends at an intersection with Nebraska Highway 15 north of David City.

After meeting Nebraska Spur 78J, it turns east, crosses the Platte River, then turns northeast and meets the U.S. Highway 275 freeway northwest of Valley.

They separate, and NE 64 goes east as a divided highway past the Elkhorn River into increasing areas of residential and commercial development and meets Nebraska Highway 31 in the Elkhorn neighborhood of Omaha.

The highway then becomes Maple Street and continues east, becoming a two lane road as it passes through the Benson neighborhood.

The east end of Nebraska Highway 64 has also been altered with the reconstruction of the Interstate 480/U.S.