The Kentucky State Guard re-designated as the Kentucky National Guard in 1912, and the unit mustered into federal service once again at Fort Thomas in February 1917.

[3] The Louisville unit was then converted and redesignated HHC 149th Armored Brigade on 1 November 1980.

[14] The 149th MEB also contains a Military Police Battalion known as the 198th MP BN.

[15] This battalion has several combat support units, and one law and order detachment.

The unit's headquarters changed 1 October 2013 to Richmond, Kentucky.