The 150th Pennsylvania Infantry was a Union Army volunteer regiment during the American Civil War.

Gettysburg was the first major battle that the 150th was in, where it held back overwhelming numbers of Confederates for several hours.

Colonel Langhorne Wister raised the 150th Pennsylvania Infantry in Philadelphia and Harrisburg in September 1862.

The regiment quickly joined the defences at Washington D.C. Its Company K, commanded by Captain David Derrickson, was detached and served as bodyguard for President Abraham Lincoln for the duration of the war, including at his stay at the Soldiers' Home.

Lieutenant-colonel Henry S. Huidekoper and Corporal J. Monroe Reisinger received the Medal of Honor while members of the regiment.