Langhorne Wesley Wister (September 20, 1834 – March 19, 1891) was a Union Army officer during the American Civil War.

Langhorne Wister served as a captain in the 13th Pennsylvania Reserve Regiment, fighting at the Battle of Gaines's Mill, where he was wounded.

Wister assumed command of a brigade on the first day of the Battle of Gettysburg after Colonel Roy Stone was wounded.

Wister was wounded a short time later that same day in the mouth with a minie ball and had to give up command.

In 1874 he was made the Republican candidate for Congress from the 18th district, but was defeated by William S. Stanger, Democrat, by 1023 majority.