[1] After the outbreak of the American Civil War in 1861, independent companies in southern Indiana were organized as part of the 6th and 8th Indiana Volunteer Infantry Regiments, and were mustered into federal service as three-month units from 22 to 26 April 1861, and mustered out of service on 2–6 August 1861 at Indianapolis.

It was mustered out of federal service on 4 November 1898 at Camp Mount, Indiana, not having served outside the continental United States.

The regimental headquarters successively relocated to Fort Wayne, Indiana, on 13 February 1932, and back to Indianapolis on 19 April 1938.

The regiment, or elements thereof, was called up to perform the following state duties: tornado relief in southern Indiana in 1925; riot control during labor troubles in Vanderburg and Warwick Counties, 22 February–1923 March 1926; 3rd Battalion for riot control during race troubles due to a lynching in Marion, Indiana, 9–11 August 1930; two companies for riot control during a coal miners’ strike at Sullivan County, 9 October–15 November 1931; entire regiment for riot control during a coal miners’ strike at the Dixie Bee Mine near Terre Haute, Indiana, 2 August–October 1932; 1st Battalion for guard and security duties in connection with the visit of President Roosevelt to Vincennes, Indiana, 14 June 1936; entire regiment for flood relief along the Ohio River, January–March 1937.

After two days of heavy fighting, resulting in high casualties for the regiment, all eastward progress had stopped.

The recapture of the Bataan peninsula enabled American forces full use of Manila Bay and its world-class deep water port.

Location of Headquarters 2nd Battalion 152nd Infantry (Mechanized) changed 1 March 1977 to Camp Atterbury; on 1 November 1979 to Columbus.

In late 2002, the 76th Infantry Brigade mobilized two battalions to provide support for an escalating campaign in the Middle East.

The 1st Battalion, 152nd Infantry, "Predators," mobilized at Camp Atterbury, Indiana, on 2 January 2003 and deployed to Kuwait in mid-February 2003.

The 1st Battalion, 152nd Infantry, employed companies in Baghdad (initially in support of the 5th Special Forces Group), Forward Operating Base Kalsu (approximately 30 miles south of Baghdad in the "Sunni Triangle"), and Convoy Service Center Scania, both of which were along Main Supply Route (MSR) Tampa.

[11] Team Gator conducted extensive joint combat patrols and enemy clearing operations in both the Ramadi and Fallujah during some of the most intense fighting of the Iraq campaign.

[11] Team Gator opened eight new police stations in Al Anbar Province, including Ramadi and Fallujah; participated in eight battalion-sized enemy clearing operations; conducted hundreds of joint patrols with Iraqi Security Forces, and killed or captured more than 100 enemy insurgents.

[11] Soldiers in Team Gator received 34 Purple Hearts, 27 Bronze Star Medals (two valor device).