It travels east, exactly 19 miles south of Madison Street for its entire route.

Two miles further east (still in Orland Park), the road intersects US 45 (LaGrange Road/96th Avenue).

In Oak Forest, the road intersects IL 50 (Cicero Avenue).

In South Holland, 159th Street intersects I-94 (Bishop Ford Freeway/Dan Ryan Expressway East Leg).

159th Street finally ends at IL 83 in Calumet City, also known as Torrence Avenue.

On the border between Hammond and Gary, The road itself finally ends at a cul-de-sac west of SR 912 (Cline Avenue).