The unit is headquartered in Orlando, Florida on the site of the former McCoy Air Force Base and is composed of two air defense artillery battalions and one field artillery battalion located at 12 National Guard armories across Central Florida.

[2] In 2016, the brigade headquarters participated in Warfighter 16–3, a corps-level exercise in Fort Carson, Colorado, that allowed the unit to practice its warfighting functions, integrate as a fully functioning staff, and achieve its training objectives of planning and executing a theater-level air defense mission.

[3] In response to Hurricane Matthew, the brigade was activated in its entirety, with 1,139 Soldiers assigned to 14 counties from 6–10 October 2016.

[4] Later in 2016, the brigade headquarters participated in Yama Sakura 71, a theater-level exercise on Kyushu, Japan to enhance the U.S. and Japan's combat readiness and interoperability, strengthen bilateral relationships, and demonstrate U.S. resolve to support the security interests of allies and partners in the Indo-Asia-Pacific region.

Brigade Soldiers rescued hundreds of persons from rising water; staffed 79 shelters for 10,260 displaced persons; distributed 1,914,864 bottles of water, 1,013,808 MREs, and 366 tons of ice at 40 Point of Distribution Sites; and conducted six security missions.