The 1788 United States House of Representatives elections in South Carolina were held on November 24 and 25, 1788 to select five Representatives for two-year terms from the state of South Carolina.

The elections resulted in two candidates in support of Washington's administration and three candidates opposed to his policies.

William L. Smith defeated two candidates in the first election of the 1st congressional district, known as the Charleston District.

Aedanus Burke defeated Robert Barnwell in the first election of the 2nd congressional district, known as the Beaufort-Orangeburg District.

1427, 4 November 1788, setting up the initial congressional districts