William Larned defeated Beals Wright in the all comers' final, 6–2, 6–8, 6–4, 6–4 to win the men's singles tennis title at the 1901 U.S. National Championships.

[2] Three-time reigning champion Malcolm Whitman did not defend his title.

[2] The event was held at the Newport Casino in Newport, R.I., United States.

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