The 1906 Oklahoma Sooners football team represented the University of Oklahoma as an independent during the 1906 college football season.
In their second year under head coach Bennie Owen, the Sooners compiled a 5–2–2 record, and outscored their opponents by a combined total of 124 to 36.
Oklahoma scheduled two games in Kansas City, Missouri, against the Kansas City Medics on October 23 and the Kansas City Athletic Club on October 27, but both games were cancelled.
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