William Clothier defeated defending champion Beals Wright in the Challenge Round 6–3, 6–0, 6–4 to win the men's singles tennis title at the 1906 U.S. National Championships.

[2] Clothier had defeated Karl Behr in the All Comers' Final.

[3] The event was held at the Newport Casino in Newport, R.I. in the United States.

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