William Larned defeated Robert LeRoy 6–2, 6–2, 6–4 in the all comers' final to win the men's singles tennis title at the 1907 U.S. National Championships.

[2] Defending champion William Clothier was unable to defend his title in the Challenge Round due to an injury in his right leg.

[3] The event was held at the Newport Casino in Newport, R.I. in the United States.

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