The 1921 Oklahoma Sooners football team represented the University of Oklahoma in the 1921 college football season.
In their 17th year under head coach Bennie Owen, the Sooners compiled a 5–3 record (2-3 against conference opponents), finished in a tie for seventh place in the Missouri Valley Intercollegiate Athletic Association (MVIAA), and outscored their opponents by a combined total of 127 to 102.
[1][2] No Sooners were recognized as All-Americans,[3] and end Howard Marsh was the only Sooner to receive all-conference honors.
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