After a victory over Oglethorpe, Alabama went winless over their next three games with losses at both Georgia Tech and Texas and a tie against Sewanee at Rickwood Field.
[3] [14] To open the season, Alabama played the Marion Military Institute at Tuscaloosa, and defeated the Cadets 110–0 in what was the most lopsided victory in the history of the Crimson Tide football program.
[18][25] After a scoreless first quarter, the Crimson Tide took a 7–0 lead after Charles Bartlett threw a 60-yard touchdown pass to Allen MacCartee in the second.
[25] Although they outplayed the Tigers throughout the game, Alabama was unable to win due to their numerous turnovers made throughout the contest.
[18][27][28] Alabama took an early 7–0 lead in the first two minutes of the game after Charles Bartlett threw a 25-yard touchdown pass to William Baty.
[29] Alabama entered their intersectional contest against undefeated Penn, coached by John Heisman, with noted sports columnist Grantland Rice having predicted a 21–0 Quaker victory.
[32] Although the entered as an underdog, The Philadelphia Inquirer noted the Crimson Tide as a veteran squad that had not reached their full potential and expected them to plat Penn tough.
[33] Before 25,000 fans at Franklin Field, Alabama upset the Quakers 9–7 in what was later recognized as one of the Crimson Tide's most significant victories in the history of the program.
[30][31] In the third quarter the Crimson Tide took the lead after Pooley Hubert fumbled on third and goal and teammate Clyde Propst recovered the ball for a touchdown.
[30][31] Twice in the fourth quarter Alabama missed field goals, leaving Penn with a chance to win late.
[35] On the Friday after their upset victory at Philadelphia, Alabama returned to Tuscaloosa and before the then largest crowd in the history of Denny Field on homecoming and defeated LSU 47–3.
Allen Graham MacCartee then extended their lead to 13–0 with his short touchdown run, and the Tigers responded with their lone points of the game on a 28-yard Roland Kizer drop kick.
Alabama then extended their lead to 27–3 at halftime behind a five-yard Hulet Whitaker run and short Bartlett pass to Al Clemens.
[41] Playing their first all-time game at the Cramton Bowl, the Crimson Tide overcame an early 6–0 deficit and defeated the Georgia Bulldogs 10–6.