Henri Cochet defeated Frank Hunter in the final, 4–6, 6–4, 3–6, 7–5, 6–3 to win the men's singles tennis title at the 1928 U.S. National Championships.

[2] It was Cochet's first U.S. Championships singles title and fourth major singles title overall.

René Lacoste was the two-time reigning champion, but did not participate that year.

The tournament used two lists of players for seeding the men's singles event; one list of eight U.S. players and one list of six foreign players.

Henri Cochet is the champion; others show the round in which they were eliminated.