The team was led by head coach Frank Thomas, in his ninth year, and played their home games at Denny Stadium in Tuscaloosa and Legion Field in Birmingham, Alabama.
The Crimson Tide opened the season with a victory over Howard before they upset Fordham 7–6 in an intersectional contest at the Polo Grounds in week two.
Alabama then went winless over their next three conference games with a tie against Kentucky followed by shutout losses to both Tulane and Georgia Tech.
[15] On the road against a favored Fordham squad, the Crimson Tide defeated the Rams 7–6 at the Polo Grounds in an intersectional matchup.
Jimmy Nelson scored Alabama's only touchdown on an 18-yard run to cap a 40-yard drive, and then Hayward Sanford connected on the extra point to give the Crimson Tide a 7–0 lead.
[16] Sanford later missed a 33-yard field goal in the first, and the Rams turned the ball over on downs at the Alabama 19-yard line to keep the score 7–0 at the end of the quarter.
[19] A week after the road win at Fordham, Alabama defeated the Mercer Bears 20–0 at Denny Stadium in the first all-time meeting between the schools.
[14][20][21] The Crimson Tide took a 7–0 first quarter lead after Paul Spencer scored on a one-yard touchdown run to cap a 42-yard drive.
[22] Although Alabama was shut out and lost by three touchdowns, Tennessee head coach Robert Neyland said of the Crimson Tide's performance that "I don't think the score indicates the difference between the teams.
[14][26] The only points of the game came in the first quarter when Charley Boswell threw a four-yard touchdown pass to Holt Rast.
[29] Two plays later, Paul Spencer scored on a short run and Bud Waites converted the extra point to give the Crimson Tide a 7–0 lead.
[29] Still down by a touchdown at the end of the third, Kentucky tied the game in the fourth on a short Noah Mullins run and Jim Hardin extra point.
Three plays later the Yellow Jackets scored on a 24-yard E. M. Wheby touchdown reception from Johnny Bosch, and after Holt Rast blocked the extra point attempt, Georgia Tech led 6–0.
[36] In their season finale against the Vanderbilt Commodores, Alabama won 39–0 at Dudley Field on Thanksgiving Day to end a two-game losing streak.