The 1941 La Salle Explorers football team was an American football team that represented La Salle College (now known as La Salle University) as an independent during the 1941 college football season.
In their second year under head coach Jim Henry, the Explorers compiled a 5–3 record and outscored opponents by a total of 119 to 55.
The team played its home games at McCarthy Stadium in Philadelphia.
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