1946 Little Three Conference football season

The Wesleyan Cardinals won the Little Three championship with a perfect 7–0 record and outscored opponents by a total of 165 to 29.

In their second season under head coach Norm Daniels, the Cardinals compiled a perfect 7–0 record, won the Little Three championship, and outscored opponents by a total of 165 to 29.

[8] The Cardinals played their home games at North Field in Middletown.

In their first year under head coach A. Barr Snively, the Cardinals compiled a 2–5 record, finished second in the Little Three, and were outscored by a total of 90 to 40.

In their 13th year under head coach Lloyd Jordan, the Lord Jeffs compiled a 3–4 record, finished third in the Little Three, and were outscored by a total of 120 to 84.