The Doane Tigers from Crete, Nebraska were led by head coach James L. Dutcher and compiled an overall record of 6–2–1 with a mark of 5–0–1 in conference play, winning the NCC championship.
The Nebraska Wesleyan Plainsmen were led by head coach George W. Knight.
They were invited to play in the Will Rogers Bowl in Oklahoma City on New Year's Day, losing to Pepperdine by a 38–13 score.
For the prior three years, Navy V-12 students comprised the majority of Peru's football team.
[29] The 1946 Wayne State Wildcats football team represented Midland University of Wayne, Nebraska, as a member of the Nebraska College Conference (NCC) during the 1946 college football season.
The United Press (UP) and the NCC coaches each selected 1946 All-Nebraska College Conference football teams.