The 1950 Mission House Muskies football team was an American football team that represented Mission House College (now known as Lakeland University) as a member of the Badger-Illini Conference (BIC) during the 1950 college football season.

In their 11th and final season under head coach Marinus Kregel, the team compiled a perfect 6–0 record, won the BIC championship, shut out its first four opponents, and outscored all opponents by a total of 97 to 21.

The Muskies won prior conference championships in 1940, 1941, and 1947, but the 1950 team compiled the first perfect season in the history of the school's football program.

Both teams were undefeated at the time, and the game was played dring Mssion House's homecoming weekend.

[1] The team played its home games at the Mission College Athletic Field in Plymouth, Wisconsin.