Milton fielded its first football team in 1899 and its last in 1981 before the school closed in 1982.
During this time, the college produced seven All-Americans and nine conference titles, in 1935, 1956, 1961, 1964, 1975, 1976, 1978, 1980, and 1981.
The Wildcats played in 419 games during this time with a record of 194–207–18.
Milton's final head coach was Rudy Gaddini, who helmed the team from 1970 to 1981, compiling a record of 61–43–5.
Two of Gaddini's players at Milton, Dave Kraayeveld and Dave Krieg, went on to play professionally in the National Football League (NFL).