The team was led by head coach Bear Bryant, in his third year, and played their home games at Denny Stadium in Tuscaloosa and Legion Field in Birmingham, Alabama.
After a victories over Houston on homecoming and on the road at Mississippi State, Alabama scored their most points in a game since the 1952 season when they defeated Furman 51–0.
After an unsuccessful bid to allow for a "sudden death" overtime period in the event of a tie in their game against Georgia Tech, Alabama defeated both the Yellow Jackets in Atlanta and Tampa at home prior to their victory over Auburn in the Iron Bowl.
[12] To open the 1960 season, the Crimson Tide scored 21 second quarter points en route to a 21–6 upset over the Georgia Bulldogs at Legion Field.
[13][14] Alabama never relinquished the lead, but Georgia ended the shutout bid late in the fourth quarter when Fran Tarkenton threw a three-yard touchdown pass to Dan Davis that made the final score 21–6.
[18] In their first road game of the season, the Crimson Tide scored a touchdown in the final minute that prevented an upset by the Tulane Green Wave in this 6–6 tie at New Orleans.
[20][21] Later in the quarter, Alabama's lead was extended further to 9–0 after Charles Binkley snapped the ball over the head of Russell Morris on a punt attempt and out of the endzone for a safety.
[23] In their annual rivalry game against Tennessee, early turnovers proved costly for the Crimson Tide in this 20–7 loss to the Volunteers at Knoxville.
[15][24] Ray Abruzzese fumbled the first play of the game for Alabama to set up the Vols' first score on an eight-yard Bill Majors touchdown pass to Charles Wyrick.
[25] A week after their first loss of the season at Tennessee, the Crimson Tide returned home and shutout the Houston Cougars 14–0 on homecoming in Tuscaloosa.
[32][33] After a one-yard Cotton Clark touchdown run extended the Alabama lead to 29–0 in the third, the Crimson Tide scored 22 fourth quarter points to win 51–0.
[35][36] The Crimson Tide then closed the game with a three-yard Bobby Skelton touchdown pass to Norbie Ronsonet and the 24-yard O'Dell field goal as time expired to win 16–15.
[38] Ultimately, Moore denied the request and cited that as a conference he was unable to violate existing NCAA rules that specified only 60 minutes for football games.
[41] After a one-yard Laurien Stapp run in the third extended the Alabama lead to 26–0, Tampa scored their only points on a three-yard Ronnie Perez touchdown pass to Charles Truelock.
[46] At Legion Field in the annual Iron Bowl game, Alabama shut out the Tigers for the second consecutive season, this time by a score of 3–0.
[48][49] Tommy Brooker connected on a 30-yard field goal for Alabama in the third and Dan Petty tied the game in the fourth for Texas with his 20-yard kick.
Alabama responded later in the period with a 14-yard Hudson Harris touchdown run to take the lead and then added a 35-yard Tim Davis field goal in the third that made the final score 10–6.
[56] Auburn scored their only points in the fourth on a touchdown pass from Frank James to Reggie Allen, and in the loss, the Tigers fumbled the ball eight times with Alabama having recovered seven of them.