The 1966 Oklahoma Sooners football team represented the University of Oklahoma during the 1966 NCAA University Division football season.

Led by first-year head coach Jim Mackenzie, they played their home games at Oklahoma Memorial Stadium and competed as members of the Big Eight Conference.

A longtime assistant at Arkansas, Mackenzie was hired in December 1965.

[1] Following one of the worst seasons in program history, the Sooners improved to 6–4, defeated rival Texas for the first time in nine years,[2] and upset undefeated rival Nebraska on Thanksgiving,[3][4] Mackenzie was named the Coach of the Year in the Big Eight.

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