The administration Nacionalista Party won seven seats in the Philippine Senate while the Liberal Party won one seat; the Nacionalistas got the majority in the Senate after having twelve of the 24 seats in the Senate prior to the election.

Jose Roy of the Nacionalistas garnered the highest number of votes and was the sole incumbent to defend his seat.

These are the Nacionalistas' Helena Benitez, Salvador Laurel and Leonardo Perez, the Liberals' sole winner Benigno Aquino Jr., and independent candidate Magnolia Antonino, who was the wife of Senator Gaudencio Antonino of the Nacionalistas (originally elected as a Liberal) who died on election eve.

Emmanuel Pelaez returns to the Senate, this time under the banner of the Nacionalistas, after last serving in 1959 as a Progressive.

Three Liberal senators lost their seats: Maria Kalaw Katigbak, Camilo Osias, and Soc Rodrigo.