Incumbent Republican Senator Edward Brooke defeated Democratic nominee John Droney in a landslide.

After losing at the convention, Norfolk County district attorney George Burke dropped out of the race and backed Droney.

However Boston City Councilor Gerald O'Leary, who was seen as the most liberal candidate, and Hampden County Register of Deeds John Pierce Lynch chose to stay in the race and face Droney in the Democratic primary.

[3] Brooke centered his campaign on experience and his sponsorship of an amendment to end the Vietnam War.

Droney ran on a law and order platform supporting Richard Nixon's conservative nominees to the United States Supreme Court and questioning the value of the Fifth Amendment.