The 1978 LPGA Championship was the 24th LPGA Championship, held June 8–11 at Jack Nicklaus Golf Center at Kings Island in Mason, Ohio, a suburb northeast of Cincinnati.

Nancy Lopez, a 21-year-old tour rookie, won the first of her three major titles, all at the LPGA Championship at Kings Island.

She finished at 275 (−13), six strokes ahead of runner-up Amy Alcott.

[3][4][5][6] It was the sixth tour win for Lopez and her fourth consecutive in 1978,[3][7] and she won the following week to run the streak to five.

[8] This was the first of twelve consecutive LPGA Championships at Kings Island; the last one in 1989 was also won by Lopez.