The 1978 NCAA Division II Lacrosse Championship was the fifth annual single-elimination tournament to determine the national champions of NCAA Division II and Division III men's college lacrosse in the United States.

A separate Division III men's championship would not be introduced until 1980.

This year's final was played at Boswell Field at the Hobart College in Geneva, New York.

[1] Roanoke defeated two-time defending champion Hobart in the final, 14–13, to win their first national title.

This was also Hobart's fifth consecutive appearance in the tournament's championship final.