Towson has competed in the Colonial Athletic Association for lacrosse since 2002, with the conference tournament format commencing in 2003.

That season, they went on to also defeat Princeton and Maryland, before falling to North Carolina in the championship game, 18–13.

In the 2001 edition of the tournament, Towson reached the Final Four, defeating Duke and Maryland, before losing to Princeton, 11–12.

In the 2013 NCAA Division I Men's Lacrosse Championship, Towson upset NCAA tournament seed Penn State to gain the Colonial conference title, losing in the first round 16–6 to #3 seed Ohio State.

Also the Tigers won 10–8 in the play-in game, followed by a close 12–10 loss to eventual finalist Notre Dame in 2015.