The Cardinals went 69–93 during the season and finished fifth in the National League East, 21 games behind the Philadelphia Phillies.

In late April, the Cardinals fired manager Vern Rapp, who had started at 7–11.

He was briefly replaced by coach Jack Krol for two games (1-1) before giving the job on a permanent basis to their former MVP third-baseman Ken Boyer, who went 61-81 the rest of the way.

On June 16, Tom Seaver of the Cincinnati Reds made history by pitching a no-hitter against the Cardinals.

Infielders Coaches Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg.