It determined that year's club champion of association football in the CONCACAF region and was played from 26 April 1980 to 2 February 1981.

The teams were split in two zones, North/Central American and Caribbean, each one qualifying the winner to the final tournament.

Surinamean team Transvaal won the two-legged series against Salvadorean Atlético Marte (2–1 on aggregate), becoming CONCACAF champions for the second time in their history.

[1] *Marathón withdrew result 2nd leg not known, Transvaal qualified.

other fixtures not known but apparently Yama Sun Oil eliminated Saint Thomas College (home country unclear) x both matches in Paramaribo