The 1987-88 Zamalek SC season was Zamalek SC association football club's 78th season in existence.

The club were crowned champions of their domestic league, the Egyptian Premier League for the sixth time in their history because of a tie breaker on goal difference against the defending champions, Al Ahly SC.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

[1] Win Draw Loss [2] Win Draw Loss [3] Juvenil Reyes withdrew.