The 2016–17 season is Zamalek's 58th season in the Egyptian Premier League and 58th consecutive season in the top flight of Egyptian football.

The club will participate in the Premier League, Egypt Cup, Super Cup, and the CAF Champions League.

The team kits for this season are manufactured by Joma.

Updated to match played 9 August 2016Source: Competitions

Updated to match played 25 September 2016Source: Competitions