The 2000–01 season is Zamalek Sports Club 90th season of football since existence in 1911, 46th consecutive season in the Egyptian Premier League, the top flight in the Egyptian football.

The club qualified to the 2001 African Cup Winners' Cup as the defending champions, earned the right to participate in the 2001 CAF Super Cup against Hearts of Oak; the winner of the 2000 CAF Champions League.

Otto Pfister

Helmy Toulan

Ashraf Kasem