The 1988 Mexican Grand Prix was a Formula One motor race held on 29 May 1988 at the Autódromo Hermanos Rodríguez, Mexico City.

The 67-lap race was won by Alain Prost, driving a McLaren-Honda, with teammate Ayrton Senna second and Gerhard Berger third in a Ferrari.

Satoru Nakajima (Lotus-Honda) and Eddie Cheever (Arrows-Megatron) made good use of the turbos' altitude advantage to qualify 6th and 7th respectively behind the 5th placed Ferrari of Michele Alboreto.

Alessandro Nannini's Benetton-Ford was the fastest 'atmo' car, some 3.3 seconds slower than Senna's pole time, while the Tyrrells of Jonathan Palmer and Julian Bailey, the turbo Osella of Nicola Larini and the Minardi of Adrián Campos failed to qualify.

The last qualifying session was dominated by Philippe Alliot's terrifying crash after he lost control of his Lola, coming out of the Peraltada curve that leads onto the pit straight.

Senna was slightly slowed by the pop-off valve opening too soon and was passed by Nelson Piquet who had actually made the best start; so good that he was almost able to out brake Prost into the first turn but the Frenchman held his line.

This, along with Senna's faster than 1987 pole time, showed the advancements in engines, tyres, aerodynamics and chassis development in the seven months between the 1987 and 1988 races.