The 1991 TranSouth 500 was the fifth stock car race of the 1991 NASCAR Winston Cup Series season and the 35th iteration of the event.

At race's end, Hendrick Motorsports driver Ricky Rudd would manage to dominate the late stages of the race to take his 12th career NASCAR Winston Cup Series victory and his only victory of the season.

It is of a unique, somewhat egg-shaped design, an oval with the ends of very different configurations, a condition which supposedly arose from the proximity of one end of the track to a minnow pond the owner refused to relocate.

This situation makes it very challenging for the crews to set up their cars' handling in a way that is effective at both ends.

Geoff Bodine, driving for Junior Johnson & Associates, would win the pole, setting a time of 30.367 and an average speed of 161.939 miles per hour (260.616 km/h) in the first round.