The 1991 Tyson Holly Farms 400 was the 25th stock car race of the 1991 NASCAR Winston Cup Series and the 42nd iteration of the event.

In the final laps of the race, taking advantage of a brake failure of the dominant driver of the day, Leo Jackson Motorsports driver Harry Gant, Richard Childress Racing driver Dale Earnhardt would mount a late-race charge to the lead, passing Gant with nine laps to go in the race to take the victory, breaking Gant's streak of four consecutive victories.

To fill out the top three, the aforementioned Harry Gant and Bud Moore Engineering driver Morgan Shepherd would finish second and third, respectively.

The speedway briefly reopened in 2010 and hosted several stock car series races before closing again in the spring of 2011.

Harry Gant, driving for Leo Jackson Motorsports, would win the pole, setting a time of 19.252 and an average speed of 116.871 miles per hour (188.086 km/h) in the first round.