The 71-lap race was won by local hero Ayrton Senna, driving a McLaren-Ford, with Briton Damon Hill second in a Williams-Renault and German Michael Schumacher third in a Benetton-Ford.
At the start, Senna got ahead of Hill but Andretti hit Berger with both crashing hard in the tyre barrier in turn 1.
Several drivers spun, with both Ukyo Katayama and Aguri Suzuki crashing on the start–finish straight on lap 27, the Footwork partially blocking the circuit and bringing out the safety car – the second time this had been seen in Formula 1 following its trial at the 1973 Canadian Grand Prix.
With the rain coming down harder, Prost lost control and, unable to avoid Fittipaldi's car, crashed into him, taking them both out of the race.
They were followed by Alessandro Zanardi, Philippe Alliot, Mark Blundell, Derek Warwick, rookie Luca Badoer, Karl Wendlinger, Andrea de Cesaris, Érik Comas, and Michele Alboreto.