Prost, returning to Formula One after taking the 1992 season off, took pole position and led the last 49 laps, winning by over a minute from Brazilian Ayrton Senna in a McLaren-Ford.
The race also marked the debut of the Swiss Sauber team, who scored their first points courtesy of Finn JJ Lehto's fifth-place finish.
This was the first time since 1974 that the first race of a season did not feature the defending Drivers' Champion in the field (in 1974, Jackie Stewart was missing as he had retired following the death of his teammate and close friend François Cevert in 1973).
The season started off in Kyalami where Prost, in his first race with Williams, took pole ahead of Senna, Schumacher, Hill, Alesi and Lehto, impressing in Sauber's first Grand Prix.
Prost won from Senna, Blundell, Fittipaldi, Lehto (who was lapped twice in early stages of the race) and Berger (he was out but was classified sixth).