The 1998–99 Detroit Titans men's basketball team represented the University of Detroit Mercy in the 1998–99 NCAA Division I men's basketball season.

Led by coach Perry Watson, the Titans played their home games at Calihan Hall as members of the Midwestern Collegiate Conference.

1 seed, they defeated UIC, Cleveland State, and Butler to win the conference tournament title and received an automatic bid to the NCAA tournament as No.

5 seed UCLA in the opening round[1] before losing to No.

[2] This 1998–99 team, which tied the school record with 25 wins, reached the NCAA Tournament in back-to-back seasons for the first, and only, time in school history.