The 1999 season was the Jacksonville Jaguars' 5th in the National Football League and their fifth under head coach Tom Coughlin.

The Jaguars hired former Carolina Panthers head coach Dom Capers to be their defensive coordinator.

The only other occasion the Jaguars opposed a team with a winning record was their 62–7 demolition of the Miami Dolphins in the divisional playoff.

Most significantly, Jacksonville missed Super Bowl champion St. Louis, despite defeating the other four teams then comprising the NFC West – including a 41–3 destruction of the San Francisco 49ers on opening day – while their non-division conference opponents were Broncos and Jets squads weakened by injuries to Terrell Davis and Vinny Testaverde.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.

The Jaguars failed to score in the second half, in part due to the Titans defense which forced four turnovers after halftime.

The game started to fall out of the Jaguars reach when in the third quarter, with the Titans up 17–14, Mark Brunell was sacked in the end zone for a safety.

On the next play, Derrick Mason returned the kickoff 80 yards for a touchdown, giving the Titans 9 points in just 17 seconds, putting them up 26–14.