The Rams finished the regular-season with a record of 13–3, and defeated the Tennessee Titans in Super Bowl XXXIV.
Having finished last in their division the previous season, the Rams also became the first "worst-to-first" team to win the Super Bowl.
It would be the franchise's only Super Bowl win during the St. Louis era; their next title would come in 2021, five years after their return to Los Angeles.
The 1999 Rams remain one of only five teams in NFL history to score more than 30 points twelve separate times in a single season.
This made Tony Banks expendable, and he was traded to the Ravens, which moved Kurt Warner from third-string to backup quarterback.
VP Shaw also acquired Marshall Faulk from the Indianapolis Colts in exchange for two draft picks.
The Rams pass defense notched five sacks and two interceptions against Ravens quarterback Scott Mitchell.
Warner threw his first touchdown pass on the first play of the second quarter, hooking up with Torry Holt on a 38-yard strike.
The Rams got off to a strong start with Kurt Warner throwing touchdown passes to Isaac Bruce on each of the team's first three possessions.
Rams right offensive tackle Fred Miller had a miserable game, committing five false starts and two holding penalties.
Hoping to rebound from the loss to Tennessee, the Rams rallied from a nine point second-half deficit in Detroit to take a 27–24 lead over the Lions with 2:42 remaining in regulation.
The Rams failed to respond, as Ron Rice would intercept Kurt Warner on the final drive, sealing St. Louis's second straight loss.
Despite dominating Philadelphia offensively, St. Louis was doomed by a seven-turnover afternoon, with three lost fumbles and four interceptions, two of which were returned for Eagles touchdowns.
With the support of running back Marshall Faulk and wide receivers Isaac Bruce, Torry Holt, Az-Zahir Hakim and Ricky Proehl, Warner completed one of the top seasons by a quarterback in NFL history by throwing for 4,353 yards with 41 touchdown passes and a completion rate of 65.1 percent.
The Rams' high-powered offense was nicknamed "The Greatest Show on Turf" and registered the first in a string of three consecutive 500-point seasons, an NFL record.
In the NFL playoffs, Warner led the Rams to a Super Bowl XXXIV victory against the Tennessee Titans.
As expected, this match between the two high powered offenses produced a lot of points (86), and yards (880, 475 by St. Louis, 405 by Minnesota).
But after falling behind 17–14, St. Louis stormed to victory with 35 consecutive second half points to open a 49–17 lead early in the fourth quarter.
The Buccaneers would only muster two field goals, and gave up a costly safety in the second quarter when a bad snap from center Tony Mayberry went over the head of rookie quarterback Shaun King and out of the end zone.
The ruling on the field was a completed catch, but was overturned on review because the ball had touched the ground before Emanuel was deemed in possession of it.
The Rams finally got into the end zone in the third quarter, with a 9-yard touchdown pass from Warner to Torry Holt, giving St. Louis a 16–0 lead.
Tennessee, however, scored 16 unanswered points with two Eddie George touchdown runs (1- and 2-yards respectively, the first with a failed two-point conversion attempt), and a 43-yard Al Del Greco field goal.
The Titans took over the ball at their own 10-yard line with 1:54 left in the game after committing a holding penalty on the ensuing kickoff.
McNair started out the drive with a pair of completions to Mason and Wycheck for gains of 9 and 7 yards to reach the 28-yard line.
Then after throwing an incompletion, defensive back Dre' Bly’s 15-yard facemask penalty while tackling McNair on a 12-yard scramble gave the Titans a first down at the St. Louis 45-yard line.