[2] However, after defeating the Bills, Colts, and Jaguars in the postseason, they lost the Super Bowl to the St. Louis Rams, 23–16 on a famous last-second tackle made by Rams defender Mike Jones at the goal line that prevented Titans receiver Kevin Dyson from scoring a potential game-tying touchdown.
In the game's closing seconds, Kevin Dyson caught a lateral on a kickoff and ran all the way down the sidelines for a touchdown.
Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve [5] at Adelphia Coliseum, Nashville, Tennessee In the team's inaugural game as the “Titans”, Steve McNair threw two touchdowns and ran in a third for a 26–15 lead with 2:55 left in the first half, but a Jeff Blake touchdown left the halftime score 26–21 Titans.
O'Donnell rebounded with a fourth-quarter score to Michael Roan and a 20–19 Titans win as Tennessee surrendered a safety on the game's final play.
at 3Com Park, San Francisco Tennessee suffered its first loss of the year as Jeff Garcia ran in a one-yard touchdown, then connected with Terrell Owens in the fourth quarter.
The Titans defense limited Jaguars quarterbacks Mark Brunell and Jay Fiedler to 196 combined yards and three interceptions.
Titans receiver Isaac Byrd’s 16-yard punt return and five carries from Eddie George for 17 yards set up a wobbly 36-yard field goal by kicker Al Del Greco.
With only 16 seconds remaining in the game, Steve Christie, the Bills' kicker, made a 41-yard field goal to put Buffalo in the lead, 16–15.
The play was named Home Run Throwback by the Titans and was developed by Special Teams Coordinator Alan Lowry.
Per the instant replay rules, the play was reviewed by referee Phil Luckett since it was uncertain if the ball had been a forward pass, which is illegal on a kickoff return.
Running back Eddie George rushed for a team playoff-record 162 yards, including a 68-yard touchdown, to help lead the Titans to victory.
McNair started out the drive with a pair of completions to Mason and Wycheck for gains of 9 and 7 yards to reach the 28-yard line.
Then after throwing an incompletion, defensive back Dre' Bly’s 15-yard facemask penalty while tackling McNair on a 12-yard scramble gave the Titans a first down at the St. Louis 45-yard line.