Penn State, appearing in their third straight title match, crushed Stanford in three games to claim the school's first ever national championship.
The Lions had fallen short in five games the previous two years, falling to Stanford in 1997 and Long Beach State in 1998.
The Nittany Lions were paced by senior All-American Lauren Cacciamani with 26 kills, six blocks and a .304 attack percentage.
Behind freshman Logan Tom's 27 kills, Stanford downed defending national champion Long Beach State in three games.
A Stanford hitting error that sailed wide sealed the national championship for Penn State, 15-7.
The win gave Russ Rose his first NCAA title as the Penn State head coach after three previous runner-up finishes, while Stanford finished as NCAA runners-up for the fourth time in school history.