The 2000 NCAA Division I women's basketball tournament began on March 17 and ended on April 2.

Pat Summitt challenged her players at halftime, and advised Tamika Catchings to move around more.

Michelle Snow blocked seven shots in the game setting a Final Four record.

Kara Lawson ran the offense, and scored a total of 19 points, of which 14 were scored in the second half, and ended up earning the Player of the Game award, helping her team win 64–54 and advance to the national championship.

The Lady Lions were led by point guard Helen Darling, who would go on to win the Frances Pomeroy Naismith Award that year.

20,060 fans were in the stands, the largest crowd ever to see a college basketball game in Pennsylvania.

Any chance of a comeback faded early, as UConn scored eight consecutive points to start the second half.

Connecticut ultimately defeated Tennessee by a score of 71–52 to win their second national championship.

The exception: First and Second rounds The following lists the region, host school, venue and the sixteen first- and second-round locations:[11] Regional semifinals and finals The Regionals, named for the general location, were held from March 25 to March 27 at these sites: Each regional winner advanced to the Final Four held March 31 and April 2 in Philadelphia at the Wells Fargo Center (Co-hosts: St. Joseph's University and University of Pennsylvania) The sixty-four teams came from thirty-three states, plus Washington, D.C. Two states, California and Texas, had the most teams with five bids.